Welcome to the Yuan Lab

Jason X.-J. Yuan, MD, PhD Professor of Molecular Medicine The Herbert Wertheim UF Scripps Institute

About the lab

Dr. Jason Yuan’s laboratory investigates the pathogenic mechanisms and develops therapeutic strategies for pulmonary vascular diseases, with a specific focus on pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with respiratory disease and hypoxia. Their research centers on understanding how membrane receptors, ion channels, and intracellular calcium signaling contribute to the development and progression of PAH. They employ advanced techniques such as patch clamp electrophysiology, digital imaging fluorescence microscopy, and traditional cell and molecular biology methods to uncover these mechanisms.

Dr. Yuan is a Professor of Molecular Medicine at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology and a Professor of Medicine at the UF College of Medicine. Additionally, he serves as the Assistant Vice President for Research at UF Health, University of Florida-Scripps Research in Florida. His academic journey began with a medical degree from Suzhou Medical College, followed by a Ph.D. in Physiology from Peking Union Medical College. He conducted postdoctoral training at the University of Maryland at Baltimore under the guidance of Drs. Mordecai P. Blaustein and Lewis J. Rubin.

Throughout his career, Dr. Yuan has explored diverse areas including hypoxic pulmonary vasoconstriction, ion channel electrophysiology in vascular smooth muscle and endothelial cells, excitation-contraction coupling in smooth muscle cells, neurons, and cardiomyocytes, as well as pulmonary vascular physiology and pathophysiology. His work continues to advance our understanding of pulmonary vascular diseases and holds promise for developing new therapeutic interventions to improve patient outcomes.

Visit the Meet the PI, Research, Publications, and Team pages.